INSTITUTE FOR SYSTEMS BIOLOGY, PACIFIC NORTHWEST NATIONAL LABORATORY ANNOUNCE PARTNERSHIP AGREEMENT TO LEVERAGE STRENGTHS IN BIOLOGY AND COMPUTATION

SEATTLE -- Monday April 26th, 2004 -- In a step that will further elevate the Pacific Northwest's profile in the emerging science of systems biology, the Institute for Systems Biology (ISB) and the Pacific Northwest National Laboratory (PNNL) announced today they have established a partnership to focus on expanding and strengthening technical capabilities of each organization in systems biology and related areas. The agreement was made public at the ISB's international symposium on Emerging Technologies and Systems Biology.

"PNNL brings to the world of biology enormous technical and computational capabilities, which are fundamental to our ability to transform biology and medicine," said Dr. Leroy Hood, ISB president. "We are excited about this partnership as it provides a unique opportunity to leverage these capabilities in a way that will further our efforts in studying and applying systems biology and ultimately lead to predictive and preventive medicine."

The goals of the partnership include building the infrastructure to solve complex biological problems faster, refining the technological and computational abilities to measure and predict complex cell behavior and strengthening existing collaborative research and development projects in systems biology.

Those current collaborations include "computational approaches to predicting protein structure," said H. Steven Wiley, chief scientist and director of the Biomolecular Systems Initiative at PNNL, the Department of Energy's Richland Wash. based laboratory. Wiley noted that an ISB computational model for protein-folding was being run on PNNL's supercomputer, which is the fifth fastest in the world.

"The ISB's expertise in instrumentation for synthesizing and analyzing genes and proteins complements our strengths in proteomics," said Wiley. Proteomics is the study of the large and complex protein sets that enable the function of biological systems.

PNNL manages the National Institutes of Health Proteomics Research Resource Center. Earlier this year, PNNL announced it had identified a record 4,000 distinctive proteins in human blood plasma, a critical step toward cataloging biological markers for early diagnosis of cancer and other diseases.

Wiley predicted the partnership will also make ISB and PNNL more competitive for several large DOE projects that will come online in the next decade, including facilities for protein-tagging and whole proteome analysis. Partnership Agreement to Leverage Strengths

About the Institute for Systems Biology
The Institute for Systems Biology (ISB) is an internationally renowned non-profit research institute dedicated to the study and application of systems biology. ISB's goal is to unravel the mysteries of human biology and identify strategies for predicting and preventing diseases such as cancer, diabetes and AIDS. The driving force behind the innovative "systems" approach is the integration of biology, computation, and technology. This approach allows scientists to analyze all of the elements in a system rather than one gene or protein at a time. Located in Seattle, Washington, the Institute has grown to seven faculty and more than 170 staff members; an annual budget of $25 million; and an extensive network of academic and industrial partners.

About the Pacific Northwest National Laboratory
PNNL is a DOE Office of Science laboratory that solves complex problems in energy, national security, the environment and life sciences by advancing the understanding of physics, chemistry, biology and computation. PNNL employs 3,800, has a $600 million annual budget, and has been managed by Ohio-based Battelle since the lab's inception in 1965.