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Julian Watts
Area of Expertise
Proteomics
Current Position
Senior Research Scientist
Degree
Ph.D., Biological Sciences, 1989, Portsmouth UK
Research Interests
Dr Watts' research interests focus on the implementation of various proteomic methodologies for the profiling of tissue, cell and blood plasma proteins, with a view to determining changes that occur as a result of a specific physiological, biological or disease state. The lab is currently focused predominantly on breast cancer, but also prostate and bladder cancer, as well as diabetes, types 1 and 2. The overarching goal is the identification of novel markers for human disease, ultimately leading to the development of new or improved predictive and diagnostic tests.
Selected Publications
Zhang H, Liu, AY, Loriaux P, Wollscheid B, Zhou Y, Watts JD, Aebersold R. Mass spectrometric detection of tissue proteins in plasma. 2007. Mol. Cell. Proteomics 6:64-71.
Tao WA, Wollscheid B, O'Brien R, Eng J, Li X, Bodenmiller B, Watts JD, Hood L, Aebersold R. Quantitative phospho-proteomic analysis using a novel dendrimer-based chemistry and mass spectrometry. 2005. Nat. Methods 2:591-598
Wollscheid B, von Haller PD, Yi E, Donohoe S, Vaughn K, Keller A, Nesvizhskii AI, Eng J, Li X, Goodlett DR, Aebersold R, Watts JD. Lipid raft proteins and their identification in T lymphocytes. 2004. Subcell. Biochem. 37:121-152.
Watts JD, Gu M, Polverino AJ, Patterson SD, Aebersold R. Fas-induced apoptosis of T cells occurs independently of ceramide generation. 1997. Proc. Natl. Acad. Sci. (USA), 94:7292-7296.
Watts JD, Affolter M, Krebs DL, Wange RL, Samelson LE, Aebersold R. Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. 1994. J. Biol. Chem., 269, 29520-29529.
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