Brian Searle, PhD

Translational Research Fellow

Brian Searle
Brian Searle is a Translational Research Fellow at the Institute for Systems Biology. Brian received his chemistry BA at Reed College in 2001. In 2004, he co-founded Proteome Software with Mark Turner and Dr. Ashley McCormack to produce and distribute cutting-edge data analysis software for proteomicists. In 2014, he returned to academia to earn his PhD with Dr. Michael MacCoss at University of Washington where he developed methods to detect and quantify proteins and phosphosites using mass spectrometry. In 2018, he joined the Institute for Systems Biology as an independent fellow to build a research program that bridges the gap between genomic and proteomic technologies to study human genetic variation. His broad research interests span the intersection of proteomics, mass spectrometry, bioinformatics, and technology development to interpret the effects of amino acid variants on both a single- and a meta-proteome level.

Proteomics, Mass Spectrometry, Bioinformatics