ISB News

NIH Awards $45M to Alzheimer’s Research

The National Institutes of Health announced $45 million in grants to support several research groups that are focused on Alzheimer's prevention. ISB's Price Lab will be working with the University of Florida to use systems biology to identify new therapeutic targets in the innate immune system. The systems approach, which ISB pioneered, allows scientists to integrate and analyze disparate data (genome, gene expression, pathology) in order to find the molecular triggers for disease.

Here's a description from the NIH site about the project:

A Systems Approach to Targeting Innate Immunity in Alzheimer’s — Dr. Todd Golde, University of Florida, Gainesville, and colleagues. $1.6 million in fiscal 2013, with the potential of $7.7 million over five years

This study builds on the genetic and pathological evidence that the innate immune system, which provides immediate defense against infection, and brain inflammation have a significant role in Alzheimer’s disease. To identify and characterize novel therapeutic targets within the innate immune system, this study will use a systems biology approach to integrate genomic, gene expression, and pathological data from Alzheimer’s patients and Alzheimer’s mouse models and analyze them in novel ways. The team will test in animal models of the disease the validity and therapeutic potential of the key factors predicted by the analysis. This has the potential to speed the discovery and testing of Alzheimer’s disease prevention and treatment therapies by targeting the immune system. (NIA support: AG 046139-01)

Learn more about how the funds will be applied:

National Institutes of Health press release

The New York Times article

USA TODAY article

International Business Times article

PM LiVE article

Related Articles

  • ISB’s Innovator Award Program rewards high-risk, cross-disciplinary research projects

    The Innovator Award Program at Institute for Systems Biology is an annual internal initiative started in 2017 that aims to stimulate creativity, innovation and collaboration within ISB, to provide funding support for high-risk, high-reward projects, and to develop new technologies and discoveries that will impact the entire research organization.

    Read More
  • Clinical Trial Explores the Effects of Health Coaching on Cognitive Function in Patients with Early-Stage Alzheimer’s

    Institute for Systems Biology (ISB) is among several organizations conducting a clinical trial testing how health coaching affects the cognitive function of patients with early-stage Alzheimer’s disease and analyzing longitudinal, multi-omic data to explore transitions in cognitive function over time.

    Read More
  • ‘GEN’ Highlights ISB Symposium

    In a feature article in “Genetic Engineering & Biotechnology News,” writer Kathy Liszewski takes readers through the minds of systems biologists whom she compares to experts in biological cryptanalysis who are hunting for the “subcellular double agents and moles” behaving nefariously and causing disease. The writer shares some key points from speakers who presented at ISB’s annual Symposium, including ISB assistant professor Dr. Naeha Subramanian and Dr. Trevor Mundel, of…

    Read More
Show More Articles