ISB News

What’s the Secret to ‘Extreme Longevity’?

3 Bullets:

  • ISB researchers and their collaborators studied a group of supercentenarians (110 years or older) to explore the genetics of ‘extreme longevity.’
  • The group performed whole-genome sequencing on 17 supercentenarians in order to look for any rare protein-altering variants associated with extreme longevity.
  • While the researchers did not find a single cause for extreme longevity within this sample size, the genomic data is now available for future studies.

By ISBUSA

The secret to “extreme longevity” is still a secret.

Title: Whole-Genome Sequencing of the World’s Oldest People
Journal: PLOS ONE
Authors: Hinco J. Gierman, Kristen Fortney, Jared C. Roach, Natalie S. Coles, Hong Li, Gustavo Glusman, Glenn J. Markov, Justin D. Smith, Leroy Hood, L. Stephen Coles, Stuart K. Kim
Link: Read the study
Quote: “Supercentenarians (110 years or older) are the world’s oldest people. Seventy four are alive worldwide, with twenty two in the United States.”

ISB researchers in the Family Genomics Group and their collaborators at Standford University, University of California Los Angeles, and the Gerontology Research Group in Los Angeles, studied a group of 17 supercentenarians (110 years or older) in hopes of discovering the genetic basis for their extreme longevity. The researchers performed whole genome sequencing of the participants in order to look for significant enrichment of rare protein-altering variants.

The results ultimately showed no significant evidence of a single cause for extreme longevity – at least not within the sample size of 17. One point of interest was that one of the supercentenarians carried a variant considered to be highly pathogenic; a variant that according to recommendations from the American College of Medical Genetics must be reported if found in someone’s genome. But this variant clearly didn’t cause any disease in this individual.

The data from the study, which includes the DNA sequences and the list of rare protein-altering variants of the 17 supercentenarians, is now available for future research on extreme longevity.

 

Related Articles

  • Dr. Jim Heath Takes Helm of ISB, Looks Toward the Future

    Jim Heath took over as president of Institute for Systems Biology on January 1. To fully appreciate Heath’s relationship with ISB, you have to go back to its early days – shortly after the research organization was founded in 2000.

    Read More
  • Genome fingerprinting

    Genome Comparison Easier with ‘Fingerprint’ Method

    ISB researchers have developed a method of capturing a personal genome as a “fingerprint,” which will have a major impact on how quickly and efficiently genome sequences are compared.

    Read More
  • New Paper on Huntington’s Disease

    Feb. 27, 2017 ISB researchers and colleagues from several institutes published a new study today in Human Molecular Genetics. The key points of the study “High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington’s disease CAG knock-in mice across multiple genetic backgrounds” are: A multi-institute collaboration mapped in high resolution the earliest effects of the Huntington’s disease mutation in mice. The study included four different genetic…

    Read More
Show More Articles