Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness


FOR IMMEDIATE RELEASE
Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness
Personal, dense, dynamic data clouds enable novel insights into mechanisms of wellness and disease, new approaches to biomarker discovery, and the empowerment of individuals to enhance their own health
SEATTLE, July 17, 2017 – The Institute for Systems Biology and Arivale, Inc. announced today results from their Pioneer 100 Wellness Project (P100), a nine-month study of 108 individuals, demonstrated that combining personal, dense, dynamic data clouds with tailored behavioral coaching can optimize wellness for individuals. These data clouds also can identify early transitions into disease states and facilitate the reversal of some disease states back to wellness. The new approach tested in this study represents the foundation for the launch of a new industry – Scientific Wellness.
“Just as the Hubble Telescope provided a new view into the universe, these data sets have been transformational in providing new insights into both human biology and disease,” said Leroy Hood, MD, PhD, president and co-founder of the Institute for Systems Biology, and senior vice president & chief science officer, Providence St. Joseph Health. “We have termed this quantitative and transformational approach Scientific Wellness, which enables individuals to improve their health and wellbeing, while generating the data necessary to optimize wellness as well as avoid or slow down the transition into certain disease states.”
The study included whole genome sequencing, the analyses of blood, urine, stool, and saliva samples collected every three months, and digital personal measurements of activity. Study investigators created personal, dense, dynamic data clouds for each participant and conducted an integrated analysis of six different types of data. The analysis included correlation of whole genome sequencing results with measurements over time of proteins, metabolites, microbiome, clinical assays and lifestyle metrics.
This study, published online in Nature Biotechnology on July 17, 2017 and in the August 2017 print issue, established thousands of statistical correlations between the data types and identified many novel data associations that provide new insights into human biology.
Multi-omic analyses build a foundation for identification of disease mechanisms, discovery of biomarkers, design of diagnostics to detect these early disease transitions, development of drug targets and ultimately, the prevention of disease. Multi-omic analysis of the participants’ data enabled the investigators to identify nearly 3,500 significant statistical correlations across data types.
Further, biomarker correlations combined with polygenic disease risks computed from Genome-wide Association Studies (GWAS) markers revealed possible ways in which genetic predisposition manifests itself through analyte changes in the blood.
Researchers combined the data-driven insights with behavioral coaching, based on actionable recommendations from genetics and clinical tests for each individual to enhance her/his health. These actions led to significant improvements in clinical markers in the P100 cohort and the subjective feeling of improved wellness for many of the participants. Behavioral coaching is a unique facet of the P100 study. The coach customized specific recommendations in consultation with the study physician and with each participant. Coaching focused on four primary quadrants: Cardiovascular, Diabetes, Inflammation, and Nutrition. The major individual recommendations fell into the categories of diet, exercise, stress management, dietary supplements, or physician referral, as relevant for each participant.
“Assessing both genetic and environmental determinants of health and their interactions takes us a significant step forward in deciphering the immense complexity of human biology and disease,” said Nathan Price, ISB associate director and professor. “Over time, this will enable us to identify the earliest transitions from wellness to disease, which is the key to both predictive and preventive care for the individual.”
In collaboration with Dr. Hood and Dr. Price, who participated in and co-led the P100 study, Jennifer C. Lovejoy, PhD, ISB affiliate ISB faculty member and Arivale’s chief translational science officer, designed and managed the clinical and coaching aspects of the study.
“It’s clear that simply providing large amounts of data to people doesn’t drive lifestyle change – in fact, it may paralyze people into inaction,” stated Dr. Lovejoy. “By combining evidence-based behavioral strategies delivered by licensed dietitian-nutritionists, we are able to bring the data to life in a way that allows people to make major improvements in their lifestyle and their wellness.”
The P100 study embodies the principles of an approach to health that is predictive, preventive, personalized and participatory (P4). “Participatory” means that the appropriately-informed individual is at the center of her/his own healthcare decision-making.
“It is empowering for individuals to have personal information about their own genes, metabolism, and disease risks,” said Gil Omenn, MD, PhD, director of the University of Michigan Center for Computational Medicine & Bioinformatics, chair of the global Human Proteome Project, (and a member of the P100 cohort). “We have entered the era of patient-centered care and Scientific Wellness.”
The study was approved by the Western Institutional Review Board. The study subjects included 59% males, 41% females; age 21-89+ years; 89% Caucasian; they were not recruited based on any specific phenotype.
After the year-long study of 108 individuals, key members of the ISB research team transitioned to Arivale, a company committed to bringing scientific wellness to consumers, when it formally launched in 2015, and this post-study analysis involved a year-long collaboration between researchers at ISB and Arivale. Arivale offers a Scientific Wellness program, based on the insights gained from the Pioneer 108 study, directly to individuals and to employees through enterprise sponsored programs. Program participants are assigned an Arivale Coach, supported by a clinical team who translate the complex scientific information into actionable recommendations to optimize wellness.
Co-authors of the paper include: Nathan D. Price, Andrew T. Magis, John C. Earls, Gustavo Glusman, Roie Levy, Christopher Lausted, Daniel T. McDonald, Ulrike Kusebauch, Christopher L. Moss, Yong Zhou, Shizhen Qin, Robert L. Moritz, Kristin Brogaard, Gilbert S. Omenn, Jennifer C. Lovejoy, and Leroy Hood.
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MEDIA CONTACT: Gretchen Sorensen, 206-794-1057, gretchen@sorensenideas.com
ABOUT INSTITUTE FOR SYSTEMS BIOLOGY
The Institute for Systems Biology is a nonprofit biomedical research organization based in Seattle, Washington. It was founded in 2000 by systems biologist Leroy Hood, immunologist Alan Aderem, and protein chemist Ruedi Aebersold. ISB was established on the belief that the conventional models for exploring and funding breakthrough science have not caught up with the real potential of what is possible today. ISB serves as the ultimate environment where scientific collaboration stretches across disciplines and across academic and industrial organizations, where our researchers have the intellectual freedom to challenge the status quo, and where grand visions for breakthroughs in human health inspire a collective drive to achieve the seemingly impossible. Our core values ensure that we always keep our focus on the big ideas that eventually will have the largest impact on human health. ISB is an affiliate of Providence St. Joseph Health, one of the largest not-for-profit healthcare systems in the United States.
ABOUT ARIVALE
Arivale is a scientific wellness company that leverages cutting-edge research, personalized data and tailored coaching supported by a clinical team to help individuals optimize their wellness. The program is based on each individual’s unique genetic makeup, data provided from external independent clinical labs and the participants lifestyle. Arivale is backed by leading scientists and investors with a strong track record in health, wellness, biotech breakthroughs and in building top-tier consumer brands. To learn more, visit www.arivale.com and follow us on Twitter and Facebook.
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Genome Medicine created a participatory medicine series, which was guest edited by Dr. Lee Hood, president of Institute for Systems Biology, and Dr. Charles Auffray, Founding Director of the European Institute for Systems Biology and Medicine. You can read the collection of articles on participatory medicine here. It includes an editorial "Participatory medicine: a driving force for revolutionizing healthcare" co-authored by Hood and Auffray that was published in December 2013….
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ISB at Town Hall Seattle: Systems Biology & Cancers
On March 27, 2014, ISB and Town Hall Seattle co-presented a panel discussion on "Systems Biology & Cancers: From Big Data to Personalized Treatment." Panelists included ISB president, Dr. Lee Hood; Dr. Tony Blau, of UW's Division of Hematology, Department of Medicine; Dr. Peter Nelson, prostate cancer researcher and oncologist at Fred Hutchinson Cancer Research Center; and moderator Dr. Eric Holland, Senior VP and Director of the Human Biology Division…
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ISB at Town Hall Seattle: Systems Biology & Cancers
On March 27, 2014, ISB and Town Hall Seattle co-presented a panel discussion on "Systems Biology & Cancers: From Big Data to Personalized Treatment." Panelists included ISB president, Dr. Lee Hood; Dr. Tony Blau, of UW's Division of Hematology, Department of Medicine; Dr. Peter Nelson, prostate cancer researcher and oncologist at Fred Hutchinson Cancer Research Center; and moderator Dr. Eric Holland, Senior VP and Director of the Human Biology Division…
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Dr. Lee Hood’s Research!America Acceptance Speech
Dr. Lee Hood received the Geoffrey Beene Builders of Science Award through Research!America (read more). Watch his acceptance speech above. UPDATE, April 12: Here's a video of the backstage interviews with all the award recipients.
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Dr. Lee Hood Receives Research!America Award
Dr. Lee Hood received the Geoffrey Beene Builders of Science Award from Research!America at a ceremony on March 12, 2014, in Washington D.C. From the Research!America Website for the Advocacy Awards (link): Geoffrey Beene Builders of Science Award (Benefactor: The Geoffrey Beene Foundation) Leroy Hood, MD, PhD, will be honored with Research!America’s 2014 Geoffrey Beene Builders of Science Award for pioneering the development of instruments that paved the way for…
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Mark Calendars for Dr. Lee Hood’s Reddit AMA on April 11
Dr. Lee Hood will participate in a Reddit AMA (Ask Me Anything) on March 24 April 11 from 10-11 a.m. PST. There will be more details posted on Reddit.com the morning of April 11. For now, feel free to look at the list of upcoming science AMAs or check out some previous science AMAs here.
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‘Decoding DNA: The Future of DNA Sequencing’: Dr. Lee Hood Appears on Australian Radio Show
Dr. Lee Hood was interviewed by Dr. Norman Swan, of the Australian Broadcasting Corporation, for the "Health Report" show. The interview aired on radio on Feb. 24, 2014. Listen to the radio segment. SEGMENT TRANSCRIPT: (Editor's note: ABC identifies Institute for Systems Biology as part of the University of Washington in the audio and in the transcript. ISB is an independent nonprofit organization and NOT a part of the UW.)…
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‘Demystifying Disease, Democratizing Health Care’
In the Feb. 26, 2014, issue of Science Translational Medicine, Dr. Lee Hood and Dr. Nathan Price, of Institute for Systems Biology, deliver an editorial stating the vision of the 100K Wellness Project. The project will track health-related data types for 100K individuals longitudinally over the course of 20-30 or more years. "Unsustainable cost increases threaten the global health care system, and further progress is stymied more by societal than…
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The New York Times Science Times Podcast: Dr. Lee Hood and 100K Wellness Project
The New York Times's Jeffrey DelViscio, who is a senior staff editor for the Science Times, interviewed our Dr. Lee Hood during the recent (Feb. 13-17) American Association for the Advancement of Science conference in Chicago for a podcast segment called "The Virtual Self." From the introduction: "…in order to truly understand health, wellness and disease, an individual human must create he or her own data cloud, which can be…
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Dr. Lee Hood and 100K Wellness Project in Yahoo! News
(ABOVE: Dr. Lee Hood, President of Institute for Systems Biology, spoke about phase one of the 100K Wellness Project while attending the AAAS conference in Chicago on Feb. 14, 2014. Photo by Kerry Sheridan/Agence France-Presse) Agence France-Presse reporter Kerry Sheridan interviewed Dr. Lee Hood on Feb. 14, 2014, about the first phase of the 100K Wellness Project. An excerpt from the article: "The Hundred Person Wellness Project, which begins next…
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One of Dr. Lee Hood’s Best Talks on Personalized Medicine
Dr. Lee Hood gave a rousing talk at the Personalized Medicine World Conference, which took place in January 2014 in Silicon Valley. In just 10 minutes, he spells out the vision he's had for more than a decade and the exciting new 100K Wellness Project that ISB is launching. It's Lee Hood at his best.
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ISB at Town Hall Seattle on March 27
As an extension of ISB's 13th Annual International Systems Biology Symposium, we are collaborating with Town Hall Seattle to hold a panel discussion. Panelists include ISB president, Dr. Lee Hood; Dr. Tony Blau, of UW's Division of Hematology, Department of Medicine; Dr. Peter Nelson, prostate cancer researcher and oncologist at Fred Hutchinson Cancer Research Center; and moderator Dr. Eric Holland, Senior VP and Director of the Human Biology Division at…
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Dr. Lee Hood’s Vision for the 100K Wellness Project
Dr. Lee Hood delivers his vision for the 100K Wellness Project. Read the news article in the journal Nature about the project.
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Nature News: ‘Medicine Gets Up Close and Personal’ – Dr. Lee Hood’s Vision for Wellness
"Even in its pilot phase, the project is unusually thorough. The ISB will sequence the whole genome of each participant at the outset. And in later phases, Hood says, the study team will also examine epigenetics: methylation and other modifications to DNA that can reflect environmental exposures. But that is just the tip of the data-collection iceberg." — From 'Medicine Gets Up Close and Personal' in Nature The journal Nature…
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From There to Here: Dr. Lee Hood
At ISB, we ask staff to share their stories about how they got "From There to Here" — because each person's path to ISB is unique. Recently, Dr. Lee Hood, our president, shared his journey from his childhood in Montana to the founding of ISB. What an incredible history.
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ISB Has Two New Patents
2014 is off to a great start for innovation in human health. ISB released two new patents in January that will make great contributions to personalized medicine. One of the patents, issued on January 27 and titled Use of Gene Expression Signatures to Determine Cancer Grade, has ISB President Dr. Lee Hood and ISB Senior Research Scientist Qiang Tian listed as inventors. Also sharing in that patent is Xiaowei Yan…
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Dr. Lee Hood: One of 50 Most Influential Scientists
Dr. Lee Hood has been named one of the top 50 most influential scientists in the world today. The list, published by www.thebestschools.org honors other leaders in science and technology such as physicist Stephen Hawking; primatologist Jane Goodall; Timothy Berners-Lee, inventer of the World Wide Web; and Peter Higgs, of Higgs boson fame. To see the full list, visit this link.
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Innovation Game Changer: Lee Hood
Dr. Lee Hood appeared in a video series produced by World Free From Cancer and Value of Innovation about five "game changers" who will help make this a cancer-free world.
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Lee Hood at World Stem Cell Summit
Genetic Engineering & Biotechnology News offered some highlights from the World Stem Cell Summit, where ISB president, Dr. Lee Hood, gave today's keynote talk: “In 5 to 10 years, you will have your genomes as part of your medical records,” Leroy Hood, M.D., Ph.D., Institute for Systems Biology, told attendees of the World Stem Cell Summit 2013 today, in San Diego. “Third-generation sequencing will be revolutionary,” he said in his…
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The Future of Healthcare is Personalized
Dr. Lee Hood, founder and president of Institute for Systems Biology, appeared on the news in New Zealand after giving a talk the previous night at the University of Auckland. Click on the image below to watch the video.
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Valerie Logan Luncheon Raises $50K for Science Education Programs at ISB
The Second Annual Valerie Logan Luncheon, which took place on Nov. 13, raised just over $50,000 (UPDATE: As of Dec. 18, 2013, the total funds raised has reached more than $60,000) for our education programs at Institute for Systems Biology. Guest speaker Julia Joo, who spent her summer as a high school intern here at ISB, shared with us the educational journey that led her to choose science as a…
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Lee Hood Selected To Receive Research!America’s 2014 Geoffrey Beene Builders of Science Award
Research!America Honors Leaders in Medical and Health Research Advocacy Glenn Close, Dr. Leroy Hood, Dr. Reed Tuckson, Kathy Giusti and the Progeria Research Foundation to Receive 2014 Research!America Advocacy Awards “This year’s honorees have transformed the lives of many individuals across the country through their remarkable achievements and advocacy for medical and health research,” said Mary Woolley, president and CEO of Research!America. “Their unwavering dedication is helping to elevate research in…
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ISB, Lee Hood on Forbes.com
John Nosta, a contributor to Forbes.com, posted this piece today and included a mention of a collaboration between Indi and ISB on a diagnostic that may help identify benign lung nodules. From Diagnosis to Treatment, Has Lung Cancer Begun To Turn The Corner? This study suggests the tremendous power of using systems biology and bioinformatics to better understand health and disease,” said Lee Hood, M.D., Ph.D., co-author of the study; co-founder…
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Lee Hood’s 75th Birthday Party Photo Gallery
Dr. Lee Hood's 75th birthday party took place at ISB on Oct. 10. Here's the photo gallery. As part of the presentations, Dr. Nitin Baliga (ISB's Director and SVP) shared a fun video he made using footage he shot during the faculty retreat. Exactly how many PhDs does it take to find a Prius battery? Watch and find out:
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Lee’s 75th Birthday and his Influence Network
Oct. 10, 2013 Today, ISB’s president and co-founder, Dr. Lee Hood, celebrates his 75th birthday. To honor this occasion we have invited individuals with a professional connection to Lee Hood to answer some questions in a survey we called “Lee Hood’s Influence Network.” In doing so, we were able to collect information on the myriad associations that Lee has formed over the decades of his illustrious career. The survey contained…
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Lee Hood Co-Founds New Spinout
PRESS RELEASE Indi Molecular Launches with $1.5 Million Seed Round Led by InterWest Partners SEATTLE and CULVER CITY, CA, September 20, 2013 – Indi Molecular, which pioneered a synthetic replacement for antibodies, today announced that it has raised a $1.5 million seed round led by InterWest Partners and joined by several angel investors. The funds will be used to further develop PCC (protein catalyzed capture) agent technology: a breakthrough process…
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Awards: ‘Seven over 70’ Best Innovators
Dr. Lee Hood, ISB’s president, was named one of Seven Over 70 best innovators in MIT Technology Review Magazine. The list recognizes leaders for their lifelong achievements in innovation. Here’s an excerpt from the story: ” ‘The physician and biologist Leroy Hood helped create the fields of genomics and proteomics by inventing the protein sequencer, the protein synthesizer, the DNA synthesizer, and, most important of all, the automated DNA sequencer. He later…
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ISB’s 2012 Annual Report is Now Online
ISB's annual report is now available. This year, we created a web site for the report. It highlights nine headlines from 2012 and also includes a stirring piece from our president, Dr. Lee Hood, on "Inventing the Future." You can explore the site at: annualreport.systemsbiology.net/2012.
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Why Does Lee Hood Travel So Much? He’s a Man on a Mission
Dr. Lee Hood believes that ISB scientists are missionaries who are spreading the power of systems biology. He is always on the road and today (June 24) he’s in Lyon, France, to attend the EISBM Symposium 2013 to give a talk on P4 medicine. Prior to arriving in Lyon, Lee was in Jerusalem to give a talk at the Israeli Presidential Conference, which drew world leaders such as Bill Clinton…
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Luxembourg-ISB Partnership: ‘An Unqualified Success’
By Hsiao-Ching Chou LUXEMBOURG JOURNAL, June 12, 2013 – At the 17th-century Neumünster Abbey, the cultural heart of Luxembourg City, a small group of some of the world’s most cutting-edge scientists gathered on June 10-11, 2013, for a symposium to discuss the future of medicine and healthcare. The consensus was clear: Achieving the greatest advances requires “no-box” thinking, cross-disciplinary teamwork and, as ISB president, Dr. Lee Hood, likes to say,…
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In the WSJ: Dr. Lee Hood Explains How Nonprofits Can Be Entrepreneurial
Our Dr. Lee Hood is a guest mentor for The Wall Street Journal's Accelerators blog. In this post, he shares how nonprofit organizations can borrow the entrepreneurial and audacious-goal-oriented spirit of startups to be successful – in addition to remaining true to their missions. An excerpt: …achieving your vision requires determined optimism, the will to never give up, a missionary passion for the concept (to convince the skeptics), a willingness…
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BBC Radio: Dr. Lee Hood on P4 Medicine
Dr. Lee Hood gave the keynote speech at the Future in Review conference on May 21. During the conference, Hood was presented with “CEO of the Year” award. In this BBC Business Daily segment, host Ed Butler talks to Hood about his P4 vision. Listen Now
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UW’s Four Peaks TV: Dr. Lee Hood Speaks About Innovation
Episode: Wellness and Science Pioneer From Four Peaks: May 24, 2013 Dr. Leroy Hood says we may not recognize our healthcare system a decade from now. Innovation will make it more predictive, personalized, preventative and participatory — his four Ps. And through Dr. Hood’s systems-based approach, we’ll be focused far more on “wellness” than on “care.” That’s just one reason why he was recognized by President Obama with one of…
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Big Money, Big Science
America’s most productive biologist on philanthropy’s role in science Leroy Hood, M.D., Ph.D., is one of America’s most successful and distinguished scientist-inventors. Four devices he created proved instrumental in decoding the human genome. He pioneered the important new field of systems biology, which studies complex biological linkages and uses technology and mathematics to map and explain interrelationships. He has been awarded seven of the highest prizes in experimental science, and…
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ISB Brain Research
ISB held a panel discussion at Town Hall to discuss the complexity of the brain. It was a thought-provoking evening that attracted about 200 attendees. If you can’t see the embedded video, click on this link: Town Hall video Read Karlyn Beer’s column in Xconomy on why systems biology is necessary for tackling the complexity of the brain. RELATED: ISB’s International Symposium: Systems Biology and the Brain info
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Dr. Lee Hood Talks P4 Medicine at Northeastern University Speaker Series
Dr. Lee Hood was among the featured speakers at Northeastern University’s Local Leaders Global Impact series, which took place on March 22, 2013. Seattle Channel taped the session.
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P4 Medicine: Antidote to Budget Woes?
Dr. Lee Hood, president of ISB, published an op-ed piece today on thehill.com’s Congress blog. His piece makes the case for P4 – personalized, predictive, preventive, participatory – medicine’s potential to shift medical care from disease-focused to wellness-focused, and thereby greatly reducing the cost of healthcare. You can read the post here. LEARN MORE ABOUT ISB’S P4 MEDICINE: The Puget Sound Business Journal featured P4 medicine in a special section…
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Publications: A ‘Google Map’ of Human Metabolism
ISB associate professor Nathan Price and Vangelis Simeonidis, a visiting scholar from Luxembourg Centre for Systems Biomedicine (LCSB is a major strategic partner with ISB), contributed to this paper – “A community-driven global reconstruction of human metabolism” – that was published today in Nature Biotechnology. An excerpt describing the collaborative project from a press release is below. An interactive map is forthcoming. From Medicalxpress.com: “An international consortium of university…
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K-12 Science Education: ISB Meets with Seattle Superintendent
One of ISB’s core beliefs is the importance of being fully engaged in how science is taught and learned at all levels – especially K-12. Our president, Dr. Lee Hood, has met with every Seattle Public Schools superintendent since 1994. Today, he met with current superintendent, Jose Banda, to discuss ISB’s ongoing partnership with the district. Superintendent Banda also toured ISB to speak with staff to learn about contemporary science…
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