ISB News

ISB develops stress test to predict how diatoms will react to ocean acidification

In a study published in Nature Communications and with implications for understanding effects of climate change, ISB researchers show microscopic phytoplankton are more resilient in an acidified environment.

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Pioneer 100 Study

Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness

Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness. Personal, dense, dynamic data clouds enable novel insights into mechanisms of wellness and disease, new approaches to biomarker discovery, and the empowerment of individuals to enhance their own health.

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ISB Engineer Hopes to Save the Sword Ferns in Seattle’s Magnificent Forest

Seattle’s Magnificent Forest at Seward Park is located within one of the nation’s most diverse neighborhoods. The 98118 zip code in southeast Seattle is home to people of all socioeconomic classes including groups of immigrants who speak more than 60 languages. Seward Park serves as an urban oasis for the community to enjoy nature, easy hikes, and access to the expansive Lake Washington. The park’s Magnificent Forest, so called because…

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‘GEN’ Highlights ISB Symposium

In a feature article in “Genetic Engineering & Biotechnology News,” writer Kathy Liszewski takes readers through the minds of systems biologists whom she compares to experts in biological cryptanalysis who are hunting for the “subcellular double agents and moles” behaving nefariously and causing disease. The writer shares some key points from speakers who presented at ISB’s annual Symposium, including ISB assistant professor Dr. Naeha Subramanian and Dr. Trevor Mundel, of…

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New Baliga Article: ‘The Promise of Systems Biology’

ISB Director and SVP Dr. Nitin Baliga contributed an article to the Missoulian Newspaper that explains the power of the systems biology approach to research. Read the full article… “Biology is complex. The need to understand this complexity drives advancements in technologies that are required to measure properties of all of the constituent parts and to understand how they interact with one another. The application of those technologies generates large…

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Jeff and Debra Arline

ISB Staffer Hosts Navy Sailors for Thanksgiving

ISB’s beloved receptionist, Debra, and her husband, Jeff, welcomed their son and some of his fellow Navy sailors to their home on Nov. 25 for a belated Thanksgiving meal. The sailors are stationed at NAS Whidbey Island and had to work on Thanksgiving Day. Jeff cooked for days to get ready to host, making family recipes for pound cake, mac-and-cheese, collard greens, and the traditional Thanksgiving turkey and fixings. We’re…

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Project Feed 1010 Featured in Good Magazine

Science matters. More than ever. We’ve always believed that if we can get teachers excited about science that they will in turn get their students excited about science. Here’s the latest about Project Feed 1010 in GOOD magazine. https://food.good.is/articles/students-aquaponics-pf1010 Excerpt: The overarching goal of PF1010 isn’t to come up with a single solution in order to feed a growing planet, but to build the infrastructure that allows more people to make…

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‘A Better Blood Test for Liver Damage’

Chemical & Engineering News highlighted ISB’s recent publication (Identifying Organ-Specific Blood Biomarkers for Acute Liver Injury) in the Journal of Proteome Research. “For many years, clinicians have relied on assays for two enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), to detect liver injury. These biomarkers have limitations, says Leroy Hood of the Institute for Systems Biology, such as a short half-life and a tendency to underreport damage in certain…

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NIH Research Matters Features ISB’s MTB Paper

NIH Research Matters published an article on our tuberculosis paper. “The incredibly large number of possible drug combinations taken together with the difficulty of growing Mtb in the laboratory make discovery of effective combination therapy extremely challenging,” Dr. Nitin Baliga says. “We hope that our systems-based strategy will accelerate TB drug discovery by helping researchers prioritize combinations that are more likely to be effective.” READ THE ARTICLE

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ISB-CGC banner image

Not Just About Collecting Data

Genetic Engineering & Biotechnology News interviewed ISB’s Dr. Ilya Shmulevich for a feature article on systems biology. “Systems biology is not just about measuring as many things as possible,” says Ilya Shmulevich, PhD, a professor at the Institute for Systems Biology. “It is also about using mathematical and computational modeling to make predictions about the system.” READ THE ARTICLE: http://www.genengnews.com/…/systems-biology-digs-deep…/5775/

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Dr. Nyasha Chambwe, a postdoctoral fellow in the Shmulevich Lab at Institute for Systems Biology, discusses some data analysis with colleague Summer Elasady.

In the News: Basketball and Biology

Congratulations to Dr. Nyasha Chambwe on being featured in the May 20 issue of Puget Sound Business Journal’s “People in Research” column. The profile reveals Dr. Chambwe’s path to ISB, starting with a full-ride scholarship to Jackson State University. She has been working on a study on pre-term birth and soon will be moving to projects related to glioblastoma and leukemia. Read the PSBJ article… Photo above: Dr. Nyasha Chambwe,…

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ISB Researcher Featured in Bio-IT World

Congrats to Sheila Reynolds (Shmulevich Lab) on being featured on the Bio-IT World Conference site for her presentation on ISB’s Cancer Genomics Cloud project. Read the Q&A here. Excerpt below: Cancer Genome Analysis at the Institute for Systems Biology Q1: How did your background in signal processing and machine learning lead you to work in cancer genome analysis at the Institute for Systems Biology in Seattle, Washington? After working in…

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In the News: How Olive Oil Led Researcher to ISB

The backgrounds of our researchers are often so fascinating. Dr. Kalli Trachana, who’s a postdoctoral fellow in Lee Hood’s lab, was featured in the Puget Sound Business Journal’s new feature called “People in Research.” The Q&A appeared in the April 15 issue of PSBJ. Read the full article here. “We have all these technologies here that can help us understand your body in completely new ways and with more granularity…we…

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Tuberculosis Research: A ‘Molecular Road Map’ to Help Understand Gene Regulation

The journal “Trends in Microbiology” recently published a spotlight article on a tuberculosis research collaboration between scientists at Institute for Systems Biology and Seattle BioMed. The paper “The DNA-binding network of Mycobacterium tuberculosis” was published in the journal “Nature Communications” (Jan. 12, 2015): “MTB employs about 200 different molecular switches to sense and respond to the shifting, hostile landscape of the host. To identify and understand the intertwining gene regulatory…

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ScienceNews Features ISB’s Bipolar Disorder Research in the News

ScienceNews posted a news brief about ISB’s latest research publication that discuss results from the first major whole-genome study of bipolar disorder. Researchers describe a breakthrough in understanding the genetic “architecture” of bipolar disorder and in identifying some of the risk genes. Read more about the research here.

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ISB’s Women in Oceanography

Photos above: (Left) Anne Thompson and (right) Mόnica Orellana as featured in “Women in Oceanography: A Decade Later.” BY ISBUSA Two of ISB’s senior research scientists are featured in the second edition of “Women in Oceanography.” Dr. Mόnica Orellana and Dr. Anne Thompson, both of the Baliga Lab, share their stories about what inspired their careers in oceanography and some of their thoughts about working in the field. The inaugural issue…

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ISB’s 100K Project A Top Story on GenomeWeb

By ISBUSA GenomeWeb announces 2014’s top-10 most-read articles on personalized medicine and the article on ISB’s 100K Wellness Project was No. 1. Here’s an excerpt from GenomeWeb’s Jan. 5 story: NEW YORK (GenomeWeb) – GenomeWeb readers in 2014 were most interested in a story about a large study investigating why some people remain healthy while others get sick. The top article was about healthcare entrepreneur Leroy Hood’s efforts to advance…

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Real Simple Magazine Quotes ISB on ‘What Exactly is Wellness?’

Above: Cover of the November 2014 issue of Real Simple Magazine A team at ISB has been working on the 100K Wellness Project, which you read about here. The November issue of Real Simple Magazine has a feature story on “What Exactly is Wellness?” It includes a mention of our wellness study and a comment from Dr. Nathan Price, ISB associate director. “Perhaps one reason why wellness programs aren’t yet…

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