ISB News

Warhol style Plasmodium

The Other Malaria: Finding New Targets for a Vaccine Against Plasmodium vivax

A new report in PLOS Neglected Tropical Diseases describes the results of an international collaboration led by researchers at ISB and Seattle’s Center for Infectious Disease Research (CIDResearch). We used mass spectrometry-based proteomics to identify nearly 2,000 proteins present in Plasmodium vivax parasites, one of the Plasmodium species that cause the disease malaria in humans. The work was done on parasites dissected from mosquito salivary glands, parasites that were in…

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Adaptive Prediction of Yeast

New Study on How Microbes Learn to Predict the Future

In a study published in Genome Biology and Evolution, researchers at Institute for Systems Biology (ISB) designed an experiment to evolve novel adaptive prediction capability in yeast by repetitively exposing it to caffeine, followed by a toxin. Remarkably, the yeast cells learned the structure of this novel environmental pattern within as few as 50 generations to use caffeine as a cue for anticipating and mitigating lethal effects of the toxin.

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Pioneer 100 Study

Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness

Institute for Systems Biology and Arivale “Pioneer 100 Study” Establishes Foundation for New Industry of Scientific Wellness. Personal, dense, dynamic data clouds enable novel insights into mechanisms of wellness and disease, new approaches to biomarker discovery, and the empowerment of individuals to enhance their own health.

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Consilience: The Museum of Awe

As part of the Institute for Systems Biology’s annual Consilience event (which took place on May 19, 2017), Dan Goods and David Delgado presented their talk The Museum of Awe. The Seattle Channel produced the video of the talk. Dan Goods and David Delgado are Visual Strategists at NASA’s Jet Propulsion Laboratory in Pasadena, California.  

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Dr. Jeff Ranish Promoted to Professor

We are pleased to announce the promotion of Jeff Ranish to Professor. Jeff has been a pioneer in the fields of mass spectrometry and gene regulation. His impressive history of innovation in mass spectrometry technology has produced novel protein-crosslinking approaches to identify large scale protein-protein interactions in complex mixtures. He has applied the innovations to important biological problems, resulting in notable findings such as the characterization of multiple topological and…

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Summer Course Success

Among ISB’s core values is the belief that we have a responsibility to share what we know. To that end, ISB hosts an annual weeklong Systems Biology of Disease Summer Course to introduce the core concepts of systems biology and their application to systems biomedicine. The course demonstrates the importance of cross-disciplinary interactions for the success of systems biology programs. Participants include graduate students, postdoctoral fellows, biomedical researchers, educators and…

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Inspiring Teachers to Inspire Students

Featured image: ISB’s Dr. Martin Shelton, left, speaks to administrators from the Central Kitsap School District. ISB’s Logan Center for Education recently kicked off a five-year Principles of Science for Principals (P4P) project with the leadership from the Central Kitsap School District. While many programs and accompanying research have been employed to support science teachers in advancing their practice, there have been few programs designed to support principals and their…

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ISB Engineer Hopes to Save the Sword Ferns in Seattle’s Magnificent Forest

Seattle’s Magnificent Forest at Seward Park is located within one of the nation’s most diverse neighborhoods. The 98118 zip code in southeast Seattle is home to people of all socioeconomic classes including groups of immigrants who speak more than 60 languages. Seward Park serves as an urban oasis for the community to enjoy nature, easy hikes, and access to the expansive Lake Washington. The park’s Magnificent Forest, so called because…

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TCGA, ISB Researchers Identify Potential Drug Targets for Leading Form of Deadly Liver Cancer

June 19, 2017 Researchers in ISB’s Shmulevich Lab and their colleagues in The Cancer Genome Atlas Research Network performed the first large-scale, multi-platform analysis of hepatocellular carcinoma, the predominant form of liver cancer. Study was published on June 15, 2017, in the journal Cell. 3 Bullets: Liver cancer is the second most common cause of death from cancer worldwide. ISB researchers and colleagues from The Cancer Genome Atlas Research Network…

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Awards: Claudia Ludwig Receives AWIS Award

Photo above: ISB’s Claudia Ludwig, MEd (center); Emily Fox, MEng, EE, PhD, for outstanding scientific advancement in STEM (left); Alyssa Taylor, PhD, for excellence in science education (right). Credit: courtesy of AWIS and photographer Martina Machackova Congratulations to Claudia Ludwig, Director of Systems Education Experiences (SEE), on receiving an award from the Seattle chapter of the Association for Women in Science for Excellence in Science Outreach. The ceremony to honor…

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Consilience: Exploring E-Textiles

As part of the Institute for Systems Biology’s annual Consilience event (which took place on May 19, 2017), Afroditi Psarra presented her talk E-textiles: hand-crafting technological artifacts. The Seattle Channel produced the video of the talk. Afroditi Psarra, PhD,  is an assistant professor at DXARTS at the University of Washington. She is a multidisciplinary artist working with e-textiles.  

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Spotlight: Ayodale Braimah, Undergraduate Intern

Congratulations to Ayodale Braimah, an undergraduate intern in the Baliga Lab, who has just been accepted into the medical school at the University of Kansas. Ayodale has been studying microbiology at the University of Washington and sought a position in the Baliga Lab in order to immerse himself in an authentic research experience in microbiology and molecular biology. He specifically wanted to better understand how organisms adapt to new environments….

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‘Scientific American’ Quotes ISB Scientist

Scientific American published an article on the human olfactory system and quoted ISB principal scientist Gustavo Glusman: “Different species specialize in smelling different things, and it’s therefore very hard to compare [them] meaningfully,” Glusman explains. He also points out the brain’s plasticity. “It is well known that when one function is lost, other functions become more nuanced,” such as increased hearing ability after vision loss. Read More

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‘GEN’ Highlights ISB Symposium

In a feature article in “Genetic Engineering & Biotechnology News,” writer Kathy Liszewski takes readers through the minds of systems biologists whom she compares to experts in biological cryptanalysis who are hunting for the “subcellular double agents and moles” behaving nefariously and causing disease. The writer shares some key points from speakers who presented at ISB’s annual Symposium, including ISB assistant professor Dr. Naeha Subramanian and Dr. Trevor Mundel, of…

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ISB Consilience: Museum of Awe

The Museum of Awe is all around us; you just have to find a door. Attendees of the 2017 Consilience event, including ISB’s Dr. Ilya Shmulevich (center), examine a mini “pop-up” experience created by NASA JPL visual strategists Dan Goods and David Delgado. The tank allows people to see particles that have come down to earth from outer space. The experience is designed as a simple reminder of the gift…

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Spotlight: Alison Paquette, Research Scientist

Congratulations to Alison Paquette who recently was promoted to Research Scientist in the Price Lab. Alison received her PhD in Experimental and Molecular Medicine at the Geisel School of Medicine at Dartmouth. She is interested in identifying molecular biomarkers that may predict preterm birth and adverse neonatal outcomes such as preeclampsia. “Pregnancy complications are not very well understood, and we are amongst the only labs really taking a systems biology…

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Martin_Shelton_PhD

ISB Q&A: Martin Shelton, Post-Doctoral Fellow

Dr. Martin Shelton is a post-doctoral fellow in the Hood Lab. Q: What are you currently working on? Our project, which I work on jointly with Rhishikesh Bargaje and Kalliopi Trachana, along with many other great collaborators both within and outside of the ISB, involves measuring the changes that occur within individual cells as populations of those cells transition from one state to another. We use, as a model system,…

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Dr. Lee Hood Receives NAS MEDAL

“Science must be enshrined in our hearts and our minds, for science is the key to inventing a future that has power, beauty, simplicity, and the ability to let all of us reach our potential,” said Dr. Leroy Hood upon receiving the National Academy of Sciences Award for Chemistry in Service to Society, which was awarded on Sunday, April 30. Watch the full acceptance speech here. Read the full citation…

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