Photo: Theo Knijnenburg, a research scientist in ISB's Shmulevich Lab, presentaed a summary of his work related to gene mutations and cancer drug sensitivity. Systems biology is about the culture as much as a scientific approach. ISB and Seattle BioMed have an inter-institutional agreement that enables the collective to benefit from shared knowledge and technology resources. For the second consecutive year, we held Lightning Talks (June 12) to allow researchers…
(Photo above: ISB’s Dr. Ilya Shmulevich describes his lab’s work in The Cancer Genome Atlas project and how ISB and FHCRC could collaborate.) Big health challenges require big science. Cancers are prime examples of overwhelmingly complex diseases that need the power of a cross-disciplinary, systems biology approach to decipher the underlying dysfunctional gene networks in order to find ways to prevent and manage the diseases and develop more effective therapies….
Emily Carlson and Sharon Reynolds, of the National Institutes of Health/NIGMS, posted a story on NIGMS's Inside Life Science as well as on Livescience.com on how systems biology is a powerful approach to studying biological networks. The article included comments from ISB scientist Aaron Brooks and senior research engineer Chris Lausted who created a network activity that they presented during the USA Science & Engineering Festival in Washington D.C. on…
ISB held its 13th Annual International Symposium: Systems Biology & Cancers on April 13-14. Please read more about our speakers and program. If you weren't able to attend or would like to refresh your memory of the talks, we have made a selection of the presentations available to view below. Or visit the playlist on ISB's YouTube channel.
ISB scientists Aaron Brooks (Baliga Lab) and Martin Shelton (Hood Lab) attended the USA Science & Engineering Festival in Washington D.C. on April 26-27. They, and ISB senior research engineer, Chris Lausted, developed an interactive network activity involving circuit boxes that represent nodes and fiber optic cables to connect them. The project and trip to D.C. were supported by funds through NIH/NIGMS and ISB’s Center for Systems Biology. From Brooks:…
Pictured above: Allison Kudla presents ISB’s Big Data Science site at the start of the meetup. ISB hosted the Seattle Vis meetup group this past Wednesday (April 30). The meetup was organized by Noah Iliinsky and facilitated by ISB’s Dick Kreisberg. The guest speakers were Ryan Lucas and Kevin Lynagh, who have created a very stylistic charting library based on a grammar of graphics. They are an independent data vis…
ISB held its 13th Annual International Symposium: Systems Biology & Cancers From Big Data to Personalized Treatment on April 13-14, 2014. Visit symposium.isbscience.net for details. Visit the gallery for images. Or visit the video playlist on ISB’s YouTube channel.
The figure above is part of a four-step procedure for the multiscale segmentation of genomic signals. 3 Bullets: Understanding systems from a multiscale perspective gives us a more detailed and holistic view of how features or functions from each scale connect and interact in a given system. The challenge is integrating the different types of information that come from each scale in an efficient way that yields the most insight….
The National Institute Of General Medical Sciences of the NIH has awarded Principal Investigator(s): Eric Deutsch, PhD, and Robert L. Moritz, PhD, a continuing R01 grant GM087221 for the ongoing development of the Trans-Proteomic Pipeline. The award titled “Development of Trans Proteomic Pipeline, an Analysis Suite for Mass Spectrometry” will continue the work of the ISB flagship proteomics analysis suite of open-source programs that has been downloaded thousands of times…
As an extension of ISB's 13th Annual International Systems Biology Symposium, we are collaborating with Town Hall Seattle to hold a panel discussion. Panelists include ISB president, Dr. Lee Hood; Dr. Tony Blau, of UW's Division of Hematology, Department of Medicine; Dr. Peter Nelson, prostate cancer researcher and oncologist at Fred Hutchinson Cancer Research Center; and moderator Dr. Eric Holland, Senior VP and Director of the Human Biology Division at…
Luis Mendoza and Eric Deutsch, of the Moritz lab, were at CINVESTAV (a federal institute in Irapuato, Mexico) last week to teach a workshop on the Trans-Proteomic Pipeline software. From Luis (pictured above): "We covered the basics of data analysis of tandem mass spectrometry data using the TPP, including the justification and theory behind the methods as well as interpretation of the results via hands-on tutorials. We had a full…
By Gustavo Glusman, ISB Senior Research Scientist ISB has joined the Global Alliance for responsible sharing of genomic and clinical data. You can read the white paper here. In the last couple of years, we (Family Genomics at ISB) moved from analyzing a handful of genomes (for the Miller Syndrome project) to analyzing over a thousand high-quality whole genomes we have in-house – in addition to the low coverage data…
Dr. Brady Bernard, Andrea Eakin, and Dr. Ilya Shmulevich, of The Institute for Systems Biology (ISB), were awarded first prize and will split $70,000 for their winning entry researching more than 25 different types of cancers and thousands of patients to gain insight into the biological networks that are disrupted or altered within a given cancer type and to identify potentially potent approved drugs that could be repurposed for the…
