ISB News

ISB Q&A: On the Systems Biology Summer Course

From our inception, we at ISB have been committed to knowledge transfer. This profound sense of responsibility to share what we learn serves as the foundation for our signature professional course on systems biology. This year’s course, which takes place July 27-31 in ISB’s conference facility, will offer a few new features, including lightning talks about systems biology technologies and a mini symposium consisting of research vignettes from nine ISB…

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It's National Cancer Research Month. Please visit aacr.org to learn more. Or please support Institute for Systems Biology directly at https://www.systemsbiology.org/support.

It’s National Cancer Research Month: How To Help

May has been designated "National Cancer Research Month" and we'd like to share a little about how ISB is using the systems biology approach to tackle some of the complexities of researching cancers. You can read our four-part series on how ISB's pioneering systems biology has made an impact and continues to clear new pathways for the cancer research field. Please visit aacr.org to learn more about NCRM. Support ISB's…

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Data Visualization from Largest Genetics Catalog of Deadliest Brain Tumor

In Cancer Research, It’s HOW That Matters

By Martin Shelton, Theo Knijnenburg and Joseph Zhou ISB Editorial Board Members The oldest existing record of cancer occurs in a 4000-year-old Egyptian papyrus. It describes, in detail, a woman with symptoms eerily similar to those of modern breast cancer patients. As for the prescribed treatment, there was simply this statement: “No cure.” Sadly, this short and assertive conclusion remains true. According to the American Cancer Society’s annual cancer statistics…

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Cancer Detection requires a cross-disciplinary, systems biology approach.

Cancer Detection: A Systems Biology Approach

By Martin Shelton ISB Editorial Board Member With the exception of cancers of the skin, mouth, and blood, it is difficult to detect cancer by sight or with a routine health screen. The natural variety that exists at the cellular level — even within cells of the same type — challenges our ability to differentiate healthy tissue from diseased. This variety, what biologists call heterogeneity, means that equally healthy cells…

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Cancer stratification: Using a systems approach to figure out cancer subtypes.

Cancer Stratification: A Systems Approach

By Theo Knijnenburg ISB Editorial Board Member When a patient receives a diagnosis of breast cancer, it’s a specific subtype of breast cancer, such as invasive ductal carcinoma. Each subtype is characterized by the shape and location of the tumor, its growth progression, prognosis and treatment. The ability to stratify, or group, cancer patients based on the specific characteristics of their cancer type, is the first step toward personalized cancer…

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Results of the steady-state Markov model. The state transition and ‘self-renewal’ probabilities required to reach the steady state, shown as heat map

Cancer Treatment: A Systems Approach

By Sui Huang and Joseph Zhou, ISB Editorial Board Members Cancer cells, for decades regarded as a uniform mass of identical (“clonal”) cells, are not like the soldiers of a traditional army, trained to act and respond in unison. Cancer cells, even within a genetic clone, express enormous individuality akin to guerrilla fighters, each with unique strengths, weaknesses and distinct behaviors. Therefore, they do not respond to an attack from…

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