ISB News

Path-seq illustration

Profiling Pathogen Gene Expression from Infected Host Cells

Researchers at ISB reported a novel method, Path-seq, to profile expression of all MTB genes within infected mice. This study presents the most comprehensive transcriptome profiling of MTB from in vivo infection and a major technical advancement for studying any host-pathogen interaction.

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Tuberculosis Research: A ‘Molecular Road Map’ to Help Understand Gene Regulation

The journal “Trends in Microbiology” recently published a spotlight article on a tuberculosis research collaboration between scientists at Institute for Systems Biology and Seattle BioMed. The paper “The DNA-binding network of Mycobacterium tuberculosis” was published in the journal “Nature Communications” (Jan. 12, 2015): “MTB employs about 200 different molecular switches to sense and respond to the shifting, hostile landscape of the host. To identify and understand the intertwining gene regulatory…

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Tuberculosis: ‘The Forgotten Plague’

PBS: American Experience Film “The Forgotten Plague” BY ISBUSA The measles outbreak and subsequent fueling of the anti-vaccination debate have monopolized headlines recently. But there’s a “plague” that causes an estimated 1.3 million deaths per year that researchers, including those at Institute for Systems Biology, are dedicated to tackling: tuberculosis. On Tuesday, Feb. 10, PBS will feature an “American Experience” film “The Forgotten Plague” on the history of tuberculosis and…

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Pushing the Molecular Switches of Tuberculosis Into Overdrive to Map Interactions

3 Bullets: Mycobacterium tuberculosis (MTB) infects more than 1.5 billion people worldwide partly due to its ability to sense and adapt to the broad range of hostile environments that exist within hosts. To study how MTB controls its responses at a molecular level, ISB researchers and their collaborators at Seattle Biomed perturbed almost all MTB transcription factor regulators and identified the affected genes. This comprehensive map of molecular switches in…

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