ISB News

New Publication in ‘Cancer Cell’

As part of The Cancer Genome Atlas project, the Shmuelvich Lab and colleagues published a paper in the journal Cancer Cell related to the rare cancer adrenocortical carcinoma. Read the summary: 3 Bullets: Adrenocortical carcinoma (ACC) is a rare, under-researched endocrine cancer with limited therapeutic options and overall poor outcome. TCGA researchers performed comprehensive analysis of 91 ACC samples to gain better understanding of potential genetic causes of the cancer….

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NIH-Led Effort – Including ISB – Launches Big Data Portal for Alzheimer’s Drug Discovery

The National Institutes of Health announced the launch of a new Alzheimer’s Big Data portal, which includes the first wave of data for use by the research community. This portal is the result of the Accelerating Medicines Partnership (AMP) program, which focuses on facilitating collaboration among government agencies, academia and industry in order to translate research more quickly to therapies. The launch of the AMP Alzeheimers Disease Knowledge Portal is…

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ISB Gets $1.7M to Study Cancer Drug Resistance

Congratulations to the Sui Huang Lab at ISB which has received a five-year $1.7 million R01 award from the National Institutes of Health and National Institute for General Medical Sciences to study cancer sub-population dynamics to understand and develop drugs to inhibit lethal cancer-drug resistance. The project proposal states that the work will: “develop a quantitative and formal framework for describing the temporal evolution of cell phenotype distribution in a…

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ISB Recieves $6.5M NIH Contract to Create Cancer Genomics Cloud with Google and SRA International (Image credit: MIT Tech Review)

Cancer Genomics Cloud: ISB and Google Featured in MIT Tech Review

(Above illustration from MIT Technology Review.) MIT Technology Review published an article about the launch of Google Genomics and included a mention of ISB’s new Cancer Genomics Cloud project. ISB received an up-to $6.5 million, two-year NIH contract in collaboration with Google and SRA International. From the MIT Technology Review article: The idea is to create “cancer genome clouds” where scientists can share information and quickly run virtual experiments as…

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ISB Awarded $6.5 Million NIH Contract to Develop ‘Cancer Genomics Cloud’ with Google and SRA International

PRESS RELEASE Institute for Systems Biology (ISB) has received a $6.5 million, up to two­-year, federally funded contract from the National Cancer Institute (NCI), National Institutes of Health (NIH). ISB is one of three organizations awarded a contract by NCI to develop a cloud-­based platform that will serve as a large­-scale data repository and provide the computational infrastructure necessary to carry out cancer genomics research at unprecedented scales. ISB’s Shmulevich…

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ISB Gets $2.3 million NIH Grant to Use Single-Cell Technology to Fight Cancer

Pictured above: Dr. Qiang Tian, left, and Dr. Edward Lin, right, discuss single-cell analysis technologies developed at Institute for Systems Biology in Seattle. September 22, 2014 – ISB has received a $2.3 million NIH grant over four years in response to NCI’s “Provocative Questions” Initiative. The project will apply ISB’s most advanced single-cell omics technologies to an innovative clinical trial for colorectal cancer (ADAPT). Principal investigator Qiang Tian, MD, PhD,…

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ISB Researchers Help Identify Four New Subtypes of Gastric Cancer That May Lead to New Targeted Treatments

3 Bullets: Gastric cancer has a high mortality rate, but current classification systems haven’t been effective in helping to identify subtypes relevant for treatment of the disease. TCGA researchers have integrated molecular data from 295 stomach tumors and have discovered four subtypes of gastric cancer. Stratification of patients into these four subtypes paves the way for the development of new personalized therapies. By Theo Knijnenburg Gastric cancer is among the…

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Cover image for ISB's 2013 Annual Report.

ISB’s 2013 Annual Report is Now Available

Institute for Systems Biology has a dizzying breadth of research projects. But when we talk about what we do, it’s how we do it that matters most. The systems approach that we pioneered and exemplify continues to distinguish our ability to tackle the most complex biological and environmental challenges today. Because of how we apply our hallmark collaborative, cross-disciplinary and integrative approach, our collective success is greater than the sum…

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LiveScience Going Viral: When Living Networks Go Awry. Story from NIH about systems biology and networks.

ISB In the News: NIH, Viral Networks and Systems Biology

Emily Carlson and Sharon Reynolds, of the National Institutes of Health/NIGMS, posted a story on NIGMS's Inside Life Science as well as on Livescience.com on how systems biology is a powerful approach to studying biological networks. The article included comments from ISB scientist Aaron Brooks and senior research engineer Chris Lausted who created a network activity that they presented during the USA Science & Engineering Festival in Washington D.C. on…

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Networks Are All Around You network activity created at Institute for Systems Biology for the USA Science & Engineering Festival.

ISB at USA Science and Engineering Festival

ISB scientists Aaron Brooks (Baliga Lab) and Martin Shelton (Hood Lab) attended the USA Science & Engineering Festival in Washington D.C. on April 26-27. They, and ISB senior research engineer, Chris Lausted, developed an interactive network activity involving circuit boxes that represent nodes and fiber optic cables to connect them. The project and trip to D.C. were supported by funds through NIH/NIGMS and ISB’s Center for Systems Biology. From Brooks:…

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NIH Awards $45M to Alzheimer’s Research

The National Institutes of Health announced $45 million in grants to support several research groups that are focused on Alzheimer's prevention. ISB's Price Lab will be working with the University of Florida to use systems biology to identify new therapeutic targets in the innate immune system. The systems approach, which ISB pioneered, allows scientists to integrate and analyze disparate data (genome, gene expression, pathology) in order to find the molecular…

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Collaboration: $16.6M TB Grant

ISB will collaborate with Seattle BioMed and ETH Zurich on a $16.6 million tuberculosis grant from the National Institutes of Health. Seattle BioMed issued this press release today: FOR IMMEDIATE RELEASE SEATTLE, AUG. 15 — Seattle BioMed has been awarded a grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, that will take a comprehensive systems approach to the problem of tuberculosis…

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It Takes A System To Know A System

Figure depicting cross-disciplinary collaborations among lab groups and usage of technologies housed in ISB’s core facilities. In August, ISB learned that our National Center for Systems Biology was renewed for $13.7 million over the next five years. This is no small feat given that only two National Centers were funded in this round and that there’s fierce competition for diminishing government grants. Here’s how your tax dollars are being put…

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ISB Featured in Google I/O Conference Keynote

We were very excited to watch the live stream of the keynote from the Google I/O conference today, because it featured work from ISB's Shmulevich Lab, which is one of a group of research organizations that has been working on The Cancer Genome Atlas (TCGA). To help visualize the TCGA data, the lab created the Cancer Regulome Explorer using Google App Engine and Google Compute Engine. Google Compute Engine is…

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