Feb. 27, 2017 ISB researchers and colleagues from several institutes published a new study today in Human Molecular Genetics. The key points of the study “High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington’s disease CAG knock-in mice across multiple genetic backgrounds” are: A multi-institute collaboration mapped in high resolution the earliest effects of the Huntington’s disease mutation in mice. The study included four different genetic…
3 Bullets: Bipolar disorder (BD) is a common, severe and recurrent psychiatric disorder with no known cure and substantial morbidity and mortality. Heritable causes contribute up to 80 percent of lifetime risk for BD. Scientists hope that identifying the specific genes involved in risk for bipolar disorder will lead to new ways to treat the disease. ISB researchers identified contributions of rare variants to BD by sequencing the genomes of…
3 Bullets: Mycobacterium tuberculosis (MTB) infects more than 1.5 billion people worldwide partly due to its ability to sense and adapt to the broad range of hostile environments that exist within hosts. To study how MTB controls its responses at a molecular level, ISB researchers and their collaborators at Seattle Biomed perturbed almost all MTB transcription factor regulators and identified the affected genes. This comprehensive map of molecular switches in…
In the Feb. 26, 2014, issue of Science Translational Medicine, Dr. Lee Hood and Dr. Nathan Price, of Institute for Systems Biology, deliver an editorial stating the vision of the 100K Wellness Project. The project will track health-related data types for 100K individuals longitudinally over the course of 20-30 or more years. "Unsustainable cost increases threaten the global health care system, and further progress is stymied more by societal than…
The National Institutes of Health announced $45 million in grants to support several research groups that are focused on Alzheimer's prevention. ISB's Price Lab will be working with the University of Florida to use systems biology to identify new therapeutic targets in the innate immune system. The systems approach, which ISB pioneered, allows scientists to integrate and analyze disparate data (genome, gene expression, pathology) in order to find the molecular…
