ISB’s research falls into these main areas. Click on any of the categories below to see a range of publications from our lab groups.

  • Microbiome

    Understanding of the human microbiome has grown exponentially over the past decade. ISB researchers are unlocking the mysteries of the human microbiome and translating our scientific knowledge into therapies for a number of complex diseases.

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  • Infectious Disease

    ISB’s systems approach is effective in making advances in global health research. Our lab groups participate in a range of areas related to infectious diseases, including tuberculosis, malaria, and dengue virus.

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  • Cell Dynamics

    Cell dynamics aims to understand biological complexity in the context of the modular organization of the cell. The three-dimensional structure of the cell gives biological systems the ability to sequester, tightly regulate, and increase the efficiency of many cellular systems. However, this structure is not static. The organelles, specialized domains, and macromolecular machines inside the cell are extremely dynamic, responding both to the internal state of the cell and to…

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  • Cancers

    The greatest impact will come from how cancers are studied versus which cancers are studied. The systems biology approach to understanding diseases is founded on the simple, profound belief that diseases are systemic disorders that emerge from the dysfunction of one or more networks that subsequently change the levels of the molecules controlled by these “disease-perturbed” networks. The cause of these network dysfunctions can be genetic and/or environmental, and as…

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    Computational Biology

    Many projects at ISB, from cancers to rare genetic diseases, entail the development of computational and mathematical approaches for modeling biological systems and analyzing large-scale measurement data sets.

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  • Brain

    Systems biology uses cutting-edge technologies to gather as much information as possible about a biological system and then uses that information to build mathematical and graphical models that account for the behavior of the system. In the case of medicine, systems biology helps define what goes wrong when a biological system becomes diseased and gives us insights on how to treat or prevent disease. The human brain and nervous system…

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  • Environment

    Systems Biology and the Environment at a Glance: Systems biology helps ISB scientists better understand how microbes interact with ecosystems. Systems biology can help scientists understand how microorganisms can clean up environmental waste and create biofuels. Systems biology can lead to predictions about how to make targeted changes to microbial networks to increase sustainability.   Systems Biology and the Environment Explained Achieving environmental sustainability is one of civilization’s historic challenges….

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  • Scientific Wellness and P4 Medicine

    P4 Medicine is Predictive, Preventive, Personalized and Participatory. Its two major objectives are to quantify wellness and demystify disease. P4 medicine is the clinical face of systems medicine. P4 medicine will make blood a diagnostic window for viewing health and disease for the individual. P4 medicine will provide new approaches to drug target discovery. P4 medicine will drive profound economic, policy and social changes. Systems biology will revolutionize the practice…

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  • Proteomics

    If DNA is the blueprint for life, then proteins are the bricks. The genes in DNA are translated into proteins, strings of amino acids that fold into three-dimensional structures. The type and order of the amino acids in a protein will change its shape and determine its special function. Proteins are the molecules that make life happen: they are the powerplants that turn food into energy, the machines that make…

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