The greatest impact will come from how cancers are studied versus which cancers are studied. The systems biology approach to understanding diseases is founded on the simple, profound belief that diseases are systemic disorders that emerge from the dysfunction of one or more networks that subsequently change the levels of the molecules controlled by these “disease-perturbed” networks. The cause of these network dysfunctions can be genetic and/or environmental, and as the disease progresses, the dynamics of the changing levels of the affected proteins should explain the biological mechanisms of the disease. As the changes caused by these disease-perturbed networks percolate throughout the system, they inevitably lead to the systemic dysfunction of multiple other organs.

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