Infectious Disease

ISB’s systems approach is effective in making advances in global health research. Our lab groups participate in a range of areas related to infectious diseases, including tuberculosis, malaria, and dengue virus.

Related Projects

  • Wilke Cohen Lyme Disease Project

    Study Utilizes Systems Approaches to Develop Diagnostics and Deeper Understanding of Chronic Lyme. ISB has received $2.13 million in transformational gifts from Jeff and Liesl Wilke; Jeff and MacKenzie Bezos; and the Bay Area Lyme Foundation to tackle chronic Lyme disease, a highly complex and often misdiagnosed disease that can be debilitating for those who do not respond to a standard course of antibiotics.

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  • Warhol style Plasmodium

    Identification of the proteins in Plasmodium vivax provide new targets for a malaria vaccine

    Scientists from ISB and the Center for Infectious Disease Research led an international collaboration to identify proteins in the malaria parasite Plasmodium vivax. P. vivax and P. falciparum cause the majority of malaria cases, but P. vivax is far less-studied, in part because it cannot be grown in the lab. The research aims to provide new targets for a malaria vaccine.

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  • Speeding Up Drug Discovery to Fight Tuberculosis

    Researchers at the Institute for Systems Biology and Center for Infectious Disease Research have deciphered how the human pathogen Mycobacterium tuberculosis is able to tolerate the recently approved FDA drug
    The study demonstrated that silencing certain regulatory genes in the bacteria, or pairing with a second drug pretomanid, disrupts a tolerance gene network to improve efficacy of killing by bedaquiline.
    This systems-approach to rational drug discovery represents significant advance in the fight against tuberculosis, which affects a third of the global population, surpassing HIV/AIDS in the number of deaths worldwide.

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