Infectious Disease

ISB’s systems approach is effective in making advances in global health research. Our lab groups participate in a range of areas related to infectious diseases, including tuberculosis, malaria, and dengue virus.

Related Projects

  • Method Developed to Profile Pathogen Gene Expression from Infected Host Cells

    Researchers at Institute for Systems Biology (ISB) have developed a method, Path-seq, that simultaneously profiles host and pathogen gene expression and is sensitive enough to explore the pathogen transcriptome in vivo. Using both Path-seq data from the human pathogen Mycobacterium tuberculosis and systems approaches, the study revealed infection-specific regulatory networks, including a network that plays a role in the composition and levels of cell wall mycolates. Path-seq represents a significant…

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  • hospital hallway

    Sepsis

    Sepsis is a very real problem for our health care system. With no reliable biomarkers, with a variety of treatment protocols, and with individual patients presenting with a myriad of complicating factors, sepsis is a moving target. ISB researchers are collaborating with the Providence St. Joseph Health network, and are aggressively working to better understand the life-threatening illness.

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  • Wilke Cohen Lyme Disease Project

    Study Utilizes Systems Approaches to Develop Diagnostics and Deeper Understanding of Chronic Lyme. ISB has received $2.13 million in transformational gifts from Jeff and Liesl Wilke; Jeff and MacKenzie Bezos; and the Bay Area Lyme Foundation to tackle chronic Lyme disease, a highly complex and often misdiagnosed disease that can be debilitating for those who do not respond to a standard course of antibiotics.

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